I have the full size main on my 356 and like it. I feel it gives me a lot of flexibility, better upwind performance and better light air performance. I have to feel it's better off the wind, too, simply because of the added sail area.
I have reefed it myself, kind of hoving to with the autopilot while i do so, and with one or two crew it's quite easy to reef. I've sailed long distances with one reef, with two and, of course, with none.
My only experience with the in-mast furling was on a chartered 38. Interestingly, the only way we could get it to work smoothly was to send two people forward to the mast and a third tending the reefing line in the cockpit. I assume something was wrong with it, and I'm glad to see others find it working so well, but I guess the moral of that story is that there could come a time when more hands are needed to undo a snag on the rollup reefing, too.
As someone above says, there are people that prefer each, and it's really a matter of personal preference. For me hoisting the main and getting underway is not too much of an issue, and a small tradeoff for what I feel is a better sail. That's probably got as much to do with the harbor we're in as anything, and in some situations you may not have the luxury of heading upwind for a bit to hoist. I can always do that, fortunately. So, lots of considerations and it really comes down to personal preferences and needs based on your own situation.