Low point in the loop
If you have a low point in the loop, there will always be some water sitting after the air blow by. Small amount of water will drain back to the lowest point and freeze if it is cold enough. You can never blow all the water out of the lines.
I use an electric air mattress pump to blow out the line and then send some pink antifreeze back into the line and then blow it out again. So if there is any drain back it will be antifreeze.
The idea is to reduce the amount of antifreeze staying in the line.