Depends on where on the Missouri. Down river from Yankton SD the current is way too strong all the way to the Mississippi. Also, there are few and VERY far between marina's, and lot's of snags. If you get into trouble, you're on your own. Have you thought about the Mississippi River? There are dams starting just north of St. Louis, and the river widens out and current is minimal usually except in the channel. Years go I lived on my sailboat for 6 months while on business in St. Louis. I was on the Alton Pool and had a BLAST! We took a 5 day trip up river and through one of the locks. It was a trip we'll never forget! I can't wait to retire and spend some time again on the Mississippi.
Don