Most diesel fuel systems have to be bled if a butterfly flaps its wings in China. It's something you want to be able to do in your sleep though in case you ever have to change a filter in a situation where you may need the engine to save your boat.
Do you have an electric fuel lift pump? If not, it's worth installing just for ease of bleeding. If you have a gravity feed tank, fuel will flow through the pump when it's off so you don't need to run it all the time. No harm in running it all the time if it's the pressure cut off type as fuel will just flow through it. Many gravity feed fuel systems need a pump to get the siphon action out of the tank started.
Wire a push button switch, you can use a regular doorbell if it's a dry location, (I assume we are talking diesel here) from the 12 volt buss with a fuse to the fuel pump. Located it so you can easily reach it with a wrench on the engine components. Have lots of the absorbent fuel clean up pads on hand.
If you don't have a manual for your engine, now is the time to track one down. Read the bleeding instructions.
Basically, you loosen connections from the tank moving forward, pushing the push button until bubbles stop coming out, tighten, and move on to the next connection. Finish at the injectors.
People will tell you that you can bleed by pushing the little lever on the engine mounted fuel pump. They are right but life is too short and already tough enough.
Give the engine a good run before you leave the dock as you may have missed a few bubbles and still have some stumbles and restarts.