How big is too big?
Ed, I have a 2001 Catalina 310 that I sail on Lake Erie. Lake Erie is shallow with steep waves, a lot of chop, and prevailing 10-20 kt SW winds in the summer with almost daily threats of thunder storms. The 310 does well on all accounts and is very easy to reef to make overpowered sailing go away. The Admiral likes this. Over 50% of the time it is just the Admiral and myself on the boat. We often have our 5 year old grandson with us and the boat is perfect for one or two little people plus a couple. The accomodations for two are as good as it gets with the centerline "real bed" in the forward cabin. The salon is smaller than most 30 footers but is fine for a couple. The aft cabin is huge and accomodqtes all of our stuff and provides ample storage for cockpit cushons, etc. The times when we have another couple or a few friends on the boat for a weekend seem to work out fine especially for sailing and cockpit lounging. Living down below for a few days would get a little cramped for four and will not work for six unless weather permits sleeping two in the cockpit. Re sailing and single handing, the boat is as easy as a Catalina 22 to sail. Sail raising and piloting is a snap especially with an autopilot to hold her into the wind and allow the Dutchman flaking system to do its thing. Docking and undocking really needs two people especially if there is any wind and/or if your slip is not sailor friendly. While I have not been on a 350 it has been described to me as a large version of the 310. I am sure it too would be a great boat. The 310 is more than enough boat for us, and I would be hard pressed to justify going to a larger, more expensive, heavier, larger sail area boat.Good luck with your decision.