IIRC, it's 9 miles off the Gulf side in the Keys, 6 miles the rest of the west coast side. However, FL law has been revised several times..for instance, the first version declared any boat with sleeping quarters and a toilet to be a "houseboat," so I could be wrong. I do know that the enviro-zealots have been pushing for years to make the rules for Gulf side apply to the Atlantic side, but so far haven't succeeded.
Oddly enough, except for a few well-meaning but misguided marinas, there are only 3 NDZs in the entire state of Florida: Key West Harbor, the Florida Keys National Marine Sanctuary, and Destin Harbor. The discharge of treated waste from a USCG certified Type I or II MSD (onboard treatment device) is legal in all other FL waters except closed (non-navigable by interstate traffic) fresh water lakes, all of which are NDZs under federal law.
--Peggie