We're not talking the Atlantic here, we're talking the Oregon (and Washington) Coast: some of the NASTIEST stuff in the northern hemisphere. Also, there's a lot of LONG runs with no real harbours. You will need to be prepared to stay offshore for days at a time, and run full days under power when the wind dies. Also realize you're going AGAINST the prevailing NW wind, so be prepared for a lot of beating.
(There's a SCARY video of boats entering La Push Harbour, but I can't find it)
That said, it's been done in smaller boats than that - I knew a guy that started down in a C&C 24 singlehanded, and he only turned back because he couldn't sleep and after 2-3 days he had had enough. I'd probably do it in a Cal 25 if I had the time, and certainly my Crown 28 would be up for the challenge.
Beware of the mouth of the Columbia!
druid