I think this is your problem. The two tanks you refer to are probably "belly tanks" and are the lowest tanks in the boat. The other two tanks (probably one in the forward compartment and one aft in the boat are above the top of the belly tanks. If your boat is like mine, you probably had leaks from the access point and possibly from the screws on the top of the belly tanks. If you leave all the tank isolation valves with water in the forward and after tank you have a static head that is trying to drain all the tanks into the lowest point, the two belly tanks. If there are leaks in the top of the belly tanks they will flow out those leaks and into the bilge. You need to remove the cabin sole and reseal the access point and the screws. You will probably find that the bottom of your cabin sole may be damaged by the long term exposure. You will also notice that when you overfill the belly tanks till the overflow vent shows water coming out you will have also overpressurized the belly tank and it may even bow up a little from the pressure.
The long and short if it is:
1. Reseal the access point and the screws on the top of the belly tanks
2. Don't over fill them. If you do, immediately open the isolation valve and pump them down to relieve the pressure.
3. Open only one tank isolation valve at a time. Because the Belly Tanks are low in the boat and provide "stability" when full. I normally draw water from the other two tanks.