Any vang system will optimize at about 45 degrees to the boom and mast base. With 45° angles youll get 71% downward and 71% forward force on the boom .... for every 1 POUND you apply youll get .71 pounds of reaction force. Placing the vang-to-boom attachment any further back on the boom than at a 45° angle will require more force - at 30° angle to the boom you'll only get .5lb downward force for every pound pulled (on a single line, no 'block & tackle'); therefore needing a .71/.5 = 145% 'stronger' vang system to do the same job of keeping the boom 'down' in comparison to a 45°.
At smaller intercept angles to the boom the vang becomes more of a 'mast ram' which can bow the lower sections of the mast for sail flattening purposes on 'floppy'/bendable masts .... but increasingly makes the boom more vulnerable to 'buckling failure' due to its now increased axial 'compression load' .... thats why I recommend that 45°; plus, the typical mast/rigging on a boat like yours isnt designed for such 'bending loads'.
So, if you have enough distance between the mast 'base' and the boom, a 45° angle (rise:run = 1:1) will usually be optimal. The strength of the boom (flexure) and strength of the mast connection are vitally important ... especially if you apply a high mechanical advantage vang system.
On a boat of your size, I'd opt for a 'compound' vang ... 2:4:1 = mechanical advantage = 8! OR a 'rigid vang' with the equivalent mechanical advantage (8:1). You 'must' be careful not to 'overstress' the such a powerful vang system or let a 'gorilla' adjust the vang when under load or you'll definitely break 'something' - like a sail or a boom, etc. The advantage of 8:1 is finger-control (from the cockpit, etc.) to adjust the vang, even when the mainsail is fully windloaded (overpowered).
I prefer high strength Harken blocks, hexaratchets, etc. for such 'high-load' vang applications.