Good advice from "TWICE AROUND." Best to check with your state law enforcement and with each state you"ll be driving through as each may have their own little differences.
And then, don't forget insurance requirements, both the tow vehicle and payload.
Last, the F-250 could do the job, but the year of vehicle, engine, type of transmission, and gear ratios come into play. Then there's the numbers, ie. axle weights, gross vehicle weight ratings, and combined vehicle weight ratings, and tounge weight. Check your owners manual for the stats. Exceed these and, legally, your head could be on a block. I think you'll find that the weight of the boat plus the weight of the trailer and you"ll be outside the envelope, or at best, marginal, for safe towing with an F-250. Sorry.
If there's any distance involved, take TWICE AROUNDS advice and go commercial.
Probally not cheap, but neither is your boat.
Hope this helps, Bill.