Dave,
I don't see your questions answered.
You will probably rarely need two anchors but if you choose to use them, set them about 20 feet apart, back until both lines are taunt with a good scope then back them in. This is not an officially sanctioned anchoring method, but it's easy, twice as secure and you'll sleep better. The boat will still swing and you may have a couple of tangled lines to contend with in the morning. But your boat will act just like the 40 footer next to you and you won't collide at night.
Under sail, drop and hang on. When it sets you'll know it.
Single handed, I've heard of folk running the anchor line to the cockpit, through blocks so you can set without leaving the helm. Once set, be sure to cleat the line at the bow normally.
If you grab a mooring, do the same but have the mooring clip back in the cockpit. Motor up next to it, grab the pendant and clip it, then pull the line so the bow is at the ball. Then go forward and attach things right.
If you have a friend along, send them forward and speak kindly while you give instructions. Have him/her use hand signals to tell you where to go. Don't YELLL! You'll look like an ass who isn't really in control. Then you ship mate will use hand signals to tell you where to go.
Don