As mentioned above, check your alignment and make sure the shaft is centered in the shaft log (you might have to haul the boat and pull the shaft seal to be sure, but you can get a rough feel by disconnecting the coupler and moving the shaft around by hand and see how far you can move it before you encounter resistance). A knock or clank when motoring, especially when it occurs even at low RPM, usually means there's inadequate clearance somewhere in the driveline and something is hitting something else. After I replaced my motor mounts last year I initially aligned the engine to the coupler, but didn't ensure the shaft was centered in the log. I ended up with a godawful clanking noise when motoring because the shaft was contacting the inside of the log. On my next haulout I was already planning to do a bunch of other driveline work and I used it as an opportunity to make sure the shaft ran true through the cutless bearing and was centered in the log. I blocked it in that position and then aligned the engine to that, and haven't had any noise since.