Oh, man, Ken, your sails look like this?
That is so bada$$! (I am so sorry, I just couldn't resist. You have a fractional rig. Your computer musta autocorrected to "fractal." Please forgive me!



)
I am not sure what your question is. "Does that configuration make a difference?" Make a difference to what?
Given that the OP was about reefing the genoa...
Most masthead rigs get the majority of power from the genoa. Most fractional rigs get the majority of power from the main sail.
From what I have read, it is still recommend to reef the main first, on either type of rig. Then, roll in some jib if you have a roller furling jib. (I don't consider small boat wire luff roller furling to be also appropriate for reefing, though some people do reef those systems.) I seldom see boats on our lake with the main reefed first. Most people I see who have roller reefing/furling will roll up the jib first, probably because it's easier for them to do. That's why learning to hove-to, and practicing reefing the main, is good to do.
Does that answer your question?
On a side note, I have also read - depending on the predominant strength of the wind in your cruising grounds, that a 150% genoa is pretty big, and that most boats do fine with a 135%. My preference would be to have a 135% with 2 reinforced reef points of about 110% and 90%, and for really light wind (like, most of our summer) I'd have a separate light air drifter. Maybe this winter I'll get a Sailrite kit and sew up that big ol' drifter...