My experience is that this is a non issue. Early Sabres, before the mid 1980s all had offset props. I sailed a 1981 Sabre 30 with a prop that was offset to starboard for about 15 years, never had an issue.
Compared to my current boat with a centered prop shaft, the only difference is the prop walk is less pronounced with the offset prop. But, this isn't really comparing apples to apples as the props are also quite different, a Martec folder on the Sabre 30 and a 3 blade Max Prop on the Sabre 362.
There are a couple of distinct advantages to the offset prop. First, when your dingy painter decides to wrap itself around the prop and shaft, it is much easier to reach it and cut it loose. Second, if you have to remove the shaft the rudder is not in the way.
If you are used to a lot of prop walk and regularly depend on the "back and fill" technique you will have a learning curve, but it is not insurmountable. There are lots of other and better reasons to walk away from a boat.
Some of the older C&Cs had a serious galvanic corrosion issue, not sure if the boat you are looking at has that issue. Seems they put an iron keel on a boat with an aluminum rudder creating a battery in the process. That would be a major issue!