Depends on how long it takes to prime
Jabsco's instructions say their macerator shouldn't run dry for more than 30 seconds. However, every second that an impeller spins dry puts some heat friction wear on it that eventually takes its toll... so the closer to that maximum tolerance, the shorter the life of the impeller, and I don't like to see any installation that allows an impeller to run dry for more than 3 or 4 seconds.As for the last inch on the bottom of the tank, you'll never get it out. Once the level in the tank drops below the top of the discharge fitting, suction is broken and the pumpout or the macerator starts sucking air...so the longer you run the macerator trying to, the more damage you do the impeller in the macerator. There's no reason to get the last inch out...it just seems to be a psychological need...and I do NOT recommend installation a discharge fitting ON the bottom of the tank to accomplish it. Just pump enough clean water through the head while pumping out to dilute it.