A little more info. There's a book called something like "Anchorages in the ICW" by Skipper Bob. Good but not comprehensive and a few of the anchorages recommended were untenable due to current and holding, still worth it though.
There are a couple of places, and
this place in particular that you will want to be very careful. The marking here is a bit dodgy and they do move. In our case because of the unclear marking (at the time) we somehow ended up on the wrong side of the river. We were motoring along showing 0.1 under the keel. When we attempted to move back over we bumped, there's a slight bottom ridge between the "wrong side" and the channel so we pressed on sloooooooowly motoring at 0.1-0.3 feet. We made it, but the Catalina 38 traveling behind us stuck and powered out a couple of times.
Lesson learned: If you get confused by the markings in these shallow areas STOP and backtrack to a known good position, then try it again.
We did run aground (on a rising tide on a sandbar) just south of the St. Lucie inlet. The ICW makes a HARD 90 away from the coast but the river continues on. At the turn of the tide the current there is insane (and we were lucky it was a king tide lol) and we literally got sucked sideways onto the bar. Be careful here.
Hell Gate was dredged recently and while narrow is a breeze.
There are a couple of "alternate" cuts in the N FL, S GA area, we did not take any of them, one looked ok the others suspicious for a vessel our size.
Especially in S FL you'll be much more comfortable/enjoyable going outside. The AICW at that point is essentially a canal between concrete walls filled with idiots trying to break speed records and the wakes just bounce back and forth between the walls. On the other hand the winding trip through the GA/SC salt marshes can be lovely and lots of places to drop the hook.
Also in S FL below, say Stuart, where the bridges are mostly Bascule and many of them, you better make sure your station keeping is good and you can back your boat. The bridge tenders want you close to the bridge to open, but at the same time there can be RIPPING currents near the bridges. We tried to figure out the timing so we could hit the bridges on their opening schedule, but we can't go fast enough to do that. As of a few months ago there are several Bascules that only open one span, one due to maintenance and a couple where they are building a fixed bridge next to it. Be extra careful here.