Not a problem, but a couple of cautions
Coming out of the Bay headed to Egmont is a no brainer. You'd have to work at it to run aground. And there is a nice anchorage on the east side of the island. Not much protection from the East, but plenty for weather from the West.The only caveat from this direction is watching out for ships. They are, of course, channel bound, and usually moving pretty fast (relatively speaking).The North and South channels are deep and wide, but there is some shoaling around so check your charts. The biggest problem is a northern passage off the North channel which passes Ft. Desoto and looks better than it is. It is easily navigable once you know it, but deceptive at first. Power boaters can usually cut the pass w/o fear, but sailors should be a little more cautious.That's about it. No real worries.