I had a couple of big block Crusaders (Chevys) in a sportfish I owned and they got great gas mileage; about 3 gallons a mile! That's right, 3 gallons a MILE. The Quadrajet carb is not really designed for slow speed operation, though it was advertised as such.
One other point to consider is that a gas engine will not run without a good battery, whereas a diesel, once started can run without any outside electricity. All your accessories will need to be spark proof (alternator, starter motor, fans, relays, etc).
There is also the safety issue of having a significant amount of gas on board, but I'm sure you know that.
In many places, especially the Bahamas, dockside gas is a great deal more expensive than diesel. Whatever you think you are saving up front, you'll pay for on the back side