I would be much more concerned about protecting the engine than the fuel economy. Check out Yanmar Help for advise. You should operate your engine within the guidelines of the manufacturer. Low RPM will shorten your useful engine life, but you will not spend as much on fuel, so maybe you will more money to purchase a rebuild or new engine.
You also need to be sure that then bottom and prop are clean to optimize fuel economy and achieve max. speed with the lowest fuel consumption.