Just a follow up for those interested. For those thinking that searching for better MPG is a waste of time.....I'm trying to say this the nicest way possible....you are in the wrong thread.
Trip has been completed. Towed the boat over 1,600 miles. And I'll share my very unscientific results.
I live in the hills of Virginia and due to the hills my initial tow MPG isn't necessarily a good comparison. However my initial tow appeared to drop the MPG of my SUV from 15 ish, unloaded, to 8 or 9 (depending on how fast I went) towing.
For the long vacation tow we removed the standing rigging, pulled the halyards into the mast so the mast was pretty clean, pushed the mast much farther forward which also lowered it (didn't lower to all the way to the Cabin as we still wanted inside and also feared damage from supporting it oddly) and removed the life lines. This was not only good from a MPG stand point but reduced wear and tear on the rigging and life lines. With those removed we seemed to get between 9-10 mpg (based on measuring with filling the tank and comparing to fuel needed to refill). This again was at driving typically at posted freeway speeds. Not a huge gain, but even with that small gain it saved 20-40 gallons of gas, 1 to 2 fuel stops and $60 - $112. Not bad for a few min of work.
I tried drafting Semis or large motor homes and that seemed to have pretty significant effect (based on the instantaneous MPG gauge from the car). This seemed to net a gain of maybe 3 MPG over not following anything. And much to my surprise it didn't require being very close to the lead vehicle, only a smidgen closer than I'd follow normally. With the semi's there was a sweet spot of too close and the boat would buffet uncomfortably, too far back and there'd be no effect at all. Following RV's had less turbulence and were more enjoyable to follow. Following car transporters or smaller trailers seem to have little benefit. (The drive was 12 hours there and 12 hours back. So yes I had a lot of time to experiment).
When driving a bit slower, say 5 mph, based on the instantaneous gage it appeared to only gain about 1 MPG. Much less than I anticipated (again with hills and traffic this is hard to gauge accurately, this isn't scientific, remember). Even when I was on some back roads doing 55 mph I was showing worse MPG on the gauge then when driving 65 mph following a semi.
Sadly I didn't spend a lot of time drafting other vehicle as it was rare to find one going the speed I wanted to and having to constantly keep the distance just right was trouble some. I preferred to set the cruise control at my desired speed and give my foot a break.
And as you already know.....Your mileage will vary