Dude, there's LOADS of places. Where on the east coast? Will you be in the ICW? Keys? I pretty much stay out of marinas although I might pick up a mooring ball if unavoidable, much prefer to be on my own hook though. We're heading south out of Hilton Head in early Nov for the Keys, we'll use marinas for fuel/water/pump out, but other than a night here and there will try to be on the hook as much as possible.
There are a lot of derelict boats clogging some of the more popular anchorages, but I think I've seen them starting to get thinned out. Certainly the group by the Harris-Saxon bridge seemed much smaller in April than last November. I have a bigger problem with private mooring balls taking up anchorage space. To me that's like going to a national park and carving out a plot of land just for yourself.
Near St. Auggies is ok, but lots of traffic, overly touristy imho, but a good stop for a couple nights. Aligator or Harrison Creek south of Fernandina is very secluded and peaceful, just north of Fernandina is nice and you can dink in and pay to use the facilities, go into town for some craft beer or ride horses on the beach, Titusville is a good spot to watch launches from, park access. Ft. Pierce has a couple good ones, but I'd recommend staying away from the R18 spot under the bridge unless its just a one or two night stay. Some good spots in the south of Lake Worth past Rybovitch, I stay away from Marine Stadium but some might like it, but there loads of places in the sounds back of Largo. Getting further down in the keys the long term anchorages get thinner on the ground and we'll for sure be watching the wind and moving when we need to for protection. This year we're going to try some places in backcountry as well.