I'm a belt and suspenders kinda guy.
I use OpenCPN to plan a (significant) trip at home, feeding the resulting route and waypoints into the chartplotter. I then print off each leg of the trip as a separate 8.5x11 page, with a bit of overlap (pre upcoming turn, post next turn), often at varying zoom levels.
The printed pages then go into plastic sleeves and into a 3 ring binder. For really significant trips .. like races a day or more in duration .. I'll spring to have the pages laminated.
I'll often mark up the page with notes, arrows to key markers or hazards, etc. This is a major point with me; while my chartplotter is fine for navigating most routes, there are times when some additional information is useful, and it's hard to draw a circle around a rock on the chart in the plotter. <g>
I do run the route in the chartplotter as well though, as it's reassuring to have the chartplotter beep near a waypoint, confirming my DR position.
Should a trip take a departure from the expected (weather or whimsy) , I do much the same. At anchor, I plan the trip on the computer, upload it to the chartplotter, then manually replot it on a paper chart. The paper chart stays in the cockpit by the tiller in a big ziplock bag.