Depends on the Engine
Modern Yanmars are self bleeding. To prove this on my 37 HP 3JH2E I changed filters, including the big Racor water separator but did not bleed the system. Then I turned off the raw water seacock and just turned the ignition key. The engine ran briefly and stopped, using up the fuel in the injector lines. Then I turned the key again and after about 10 seconds it started and ran perfectly.This is not a procedure to be recommended as the starter motor is not rated for continuous running and the muffler will fill up with seawater if the seacock is not closed. It would help to pull the valve lifter but I didn't bother to.Why did I do it? Well, if motor sailing on port tack and the fuel level is low, the pickup tube can suck air and the engine will stop. It would be a nuisance, possibly dangerous, to have to bleed the whole system whilst underway.However it did prove the point and verified Yanmar's claim for a self bleeding engine.