Oh yeah, I'm always listening...and if you didn't try to pump out while you had vent line off the tank, you haven't ruled out a blocked vent.
The two most common locations for a vent blockage are the vent thru-hull and the other end of the vent line--that end of the hose and the vent fitting on the tank. Start by cleaning out the thru-hull...use a screwdriver blade, ice pick--whatever works. If that doesn't result in a spew out the vent, you'll need to relieve the pressure before removing the vent line from the tank to clean them out...so open the deck pumpout fitting VERY CAREFULLY with a hose at the ready. Be sure you're UPwind of it! Scrape out that end of the vent line and the vent fitting on the tank...replace the vent line.
If there's a filter in the vent line, remove it...once a filter gets wet--which can happen when a tank is overfilled or even due to heeling--the charcoal swells and blocks the vent...one of the reasons why vent filters aren't recommended for use on most sailboats.
Once you've actually cleared the vent, try to pump out again. I think you'll prob'ly succeed this time. If you don't, there very well could be a clog in the tank discharge...most likely in the tank at the discharge fitting, in which case my money is on a wet wipe.
So clear the vent and let me know if that solves the problem.
I'm guessing that you're fairly new at dealing with marine toilets and holding tanks. The title of my book (see link in my signature, just click on the title). The title (my publisher's idea) is a bit misleading...'cuz although it does deal with every source of odor on a boat and how to cure, or better yet PREVENT 'em, it's actually a comprehensive "marine toilets and sanitation systems 101" manual that explains the laws, describes all the types of systems and how they work, and will help you learn how to operate and maintain your system to prevent 99% of problems instead of having to cure 'em. 'Cuz you get to do any preventive maintenance on your terms when it's convenient...the need to cure a problem never happens when it is! And I'm always glad to answer any questions it doesn't.
--Peggie