I have never experienced Rustoleum bottom paints and was not aware of that. I understand the topside paints.
When trailering boats keeping them in waters for a brief period, then anti fouling paints are not suggested. If you want the added protection, then apply barrier coats but please make sure the hull is dry before applying. It takes weeks for the fiberglass hull to dry out properly. As for blisters, you can dremel those out, filling with two part epoxies and I use Water Tite. Then I would sand and put a couple of applications of barrier coat on top and repaint with anti fouling paint vs. painting the rest of the hull if not needed.
There are many applications of paints and you are correct to check with the locals but again the boat being trailered all the time does not need to be painted. Now leaving in the water is another issue due to barnaacles in salt water, zebra musscles in the Great Lakes are and now some hard slime algea adhering to the hull.
If leaving the boat in the water year round, then I would apply an anti fouling but check locally what is best to apply. If you are going to temporarily going to leave a trailerable in the water say for 6 months for one in the Great Lakes and wants the paint to be good for the following season, a softer paint like West Mareine CCP or comprobable Interlux brand will do nicely. Otherwise most antifouling paints will dry out and be no good for the following season if left out more than 60 days out of the water.
Alot really depends on what you are going to do with the boat and then checking with the locals as to the best solution where the boat will be at.