Two Units
I do not have a 45, but installed air conditioning on my 34. Running distribution ducting is a royal PIA. It is much easier to install multiple units on your boat. Your boat will be zoned so the forward and aft area can be set a different temperatures or so that one area can be totally turned off to save amperage, for instance when running the generator. I considered installing a 12,000 BTU unit in the main cabin of my 34 and a 5,000 in the forward area. If I lived in Texas or south Florida I would have followed through, but here in the Chesapeake we have been happy with only the 12,000 and a strong circulating fan.