I'm not an authority on the subject. Don't do as I do, only analyze the following facts:
The last impeller was in there from Sep, 2011 till April, 2014. No change in eye-observed water flow, no change in the impeller condition when removed vs the new one I replaced it with. At least, not that I could tell. I flicked the vanes around, pulled on it, stuck my eyeballs up to it, chewed on it, sniffed it. Looked the same.
I used the engine every weekend during the on-season weather-permitting, and a couple during the off. Also, I start the engine at lease once during the long part of winter inactivity, then re-introduce the anti-freeze. Boat stayed in the water last 3 winters, with the pump full of AF. I'll have to haul it this coming winter for paint and maint.
I think sitting for a long time can cause problems for the impeller. Maybe the AF exacerbates that.
Motor is Universal M-18. Oberdorfer pump.