Eric, I figured Ed would be a wealth of information. When I bought my boat 9 years ago, I didn't even consider the ICW bridges.
BTW my mast clearance 60'5". Not sure what I was thinking. But I believe that there are parts of the ICW where it would be a problem.
There's one bridge on the AICW in the NC section (south end of the Alligator Pungo canal) that's 'usually' at 63ft. due to 'wind tides'. Most other 'problem' bridges are so marked for the 'lowest' part of the curved span over the water (side of the channel) or the height to the lowest portion of the midspan marker lights; most will be actual 65 ft. at mid span. When in doubt ask the nearest bridge tender - Ch 13 in VA and NC.
Consider 10-12 hour days at 6 knots average = 60-70 nMi.
When transiting the Delaware Bay leave Cape May Point 'just before' the turn of the tide 'up' the bay ... and you can 'ride the tide' all the way up and have correct current direction even in the C&D canal.
Dont run against the tide with a NW or SE wind howling on the Del. Bay -- wait it out. If there were heavy rains in Penna. and Western NJ, expect 'heavy' current against you - all the way.
When rounding Cape May Point (at slack tide) use the 'inside route' to save 1-2 hrs travel out and around the shoals. The inside route will bring you 'almost' as close to the point so that you can almost spit on the land .... follow your chartplotter carefully, its a shallow and 'winding' course close to the beach.