...and can be quite a nice trip. In September of 2010 we took a Tartan 372 from Lake Erie south and eventually to the Bahamas. It took 3 months to get to the Florida Keys, then 3 months in the Bahamas, and then back to Lake Erie in July. Here is a link to our blog which might give you some idea of what to expect:
http://tartan372.blogspot.com
The blog also has a link to a photo album of the trip.
You'll need to take the mast down for the Erie Canal, and put it back up on the Hudson River. Our Tartan draws 5 and a half feet which wasn't a major problem.