Both have (dis)advantages
A wheel brake is mechanical (non-electric), an autopilot electrical, that suggests limitations which may or may not come into play. As to singlehandling, my auto cannot keep up with particular wave conditions and can be slow to react. The brake also could be a problem, if not a disaster, in rough seas. (The 27, at least the shoal draft, "feels" the waves.)Using either at anchor or dock if there is current or wave action may work but you might be listening to the auto correcting all night. Suggest you define the problem you really want to solve and look at the pros and cons of each, or get both.Andy"Baroque"