My H280 has a single lever transmission / throttle, and I assume yours does too. You may be referring to the transmission disengagement button on the throttle. You want to disengage the transmission, so ypu can give the engine throttle, but in neutral.
I also have a 2GM20F in my current boat (O’Day 322). To start on launch day, I do the following..
1) ensure water intake thruhull is open
2) ensure batteries are charged
3) ensure transmission is in neutral
4) if it is cold out, I may leave the throttle way down, and turn the engine over for a few seconds first. Or as
@Ralph Johnstone suggested, pull the fuel cut off plunger up and crank for a few seconds. The idea is to generate a little heat in the cylinders before adding fuel. The 2GM20 F doesn’t have glow plugs.
5) move throttle to about 50% and crank it over…listen for it to start. If no joy, stop cranking after 5-7 seconds, then try again. we do need to be careful about cranking too long and creating a hydro-lock. Bad news. If she won’t start with a couple of 5 second cranks, CLOSE the thruhull. Better to ruin an impeller than to cause a hydro-lock.
6) once it starts to catch, reduce throttle to fast idle and check exhaust for water flow…but on the 280, exhaust is under water…so listen to tone of exhaust. It should not sound too “hollow”.
The 2GM20F is a small but reliable and fairly simple engine….just needs clean fuel (and no air in it), air intake, and compression to run.
Good luck. Hope she fires right up.
Greg