Can do!
I'm not an experienced sailor by any means and I learn something everytime, but I sail my 37.5 by myself. When I do, I usually only put out the jib and don't raise the main. That's because the mail is such a pain to get down by myself because I can't get to the halyard at the mast. I tack by heaving to. Yes, I have an autopilot. I don't think I'd try it without one especially since my post wheel brake is totally useless. I do six knots regularly with just a 135 jib. It's comfortable, I'm not heeled over terribly and I can relax. Sometimes I go out where there is no one around and heave to, listen to some classical music and nap for 15 minutes or so. Makes me love life more.