Try I-5
The trip from SF to the Straits of Juan DeFuca is one of the most infamous around. North of SF the West Coast has few harbors, lots of fog and high winds/seas, virtually always on the nose, all year round. Entering most harbors requires crossing a bar that requires critical timing of the tides and weather. Unless you have a real desire for the experience of that particular passage, I'd consider having the boat trucked up. Quicker, likely less wear & tear on the boat. The cost is comparable when you consider the fuel, time off work (assuming you're still working), crew difficulties, time lost waiting for weather windows in harbors where you have no vehicular transportation, etc.