Done it several times. Last jump from civilization is Marco. Next stop is either somewhere in the Everglades or if you have enough daylight, one long day from Marco to Marathon.I'm on a Hunter 45 Legend and need to bring her around next month from St Pete to Daytona. I would love to hear any tips or advice you can share, and a safe route would be incredible!
A common anchorage in the Everglades is Little Shark River. A lot of people complain about bugs there be we've had pretty good luck. You can also anchor anywhere near the everglades just off shore.
Once in Marathon you have several options. Several marinias or the City's mooring field.
Its a two day trip from Marathon to Miami. We always anchor at Rodriques Key. Rodriques Key is also a popular jump off if you are going to Bimini. After Miami its bassically an offshore trip, going in at night with sereral options.
Private message me if you have specific questions.