No different on a 450 than on any other boat
It must be within 6' of the toilet (or pretty close to that), so even though you can connect two heads to one Lectra/San, you cannot connect both to the same unit if they're at opposite ends of the boat. However, since you'll need a holding tank for use in "no discharge" harbors and marinas anyway, I recommend you put a L/S on the most-used toilet and keep the other one on a holding tank. You can just lock the door to the one that has a L/S while you're in "no discharge" waters.The Lectra/San has to have salt water in order to work...so if you keep your boat in MO, you'll either have to add salt to each flush by pouring it down the toilet, or add the optional salt feed tank. Alternatively, you might consider the PuraSan instead...it's a fresh water version of the Lectra/San. However, it's only certified for use with two toilets: the Raritan Crown II and the Raritan Atlantes...which means you'd have to replace at least one toilet unless it's one of those.The complete specs for the Lectra/San and the PuraSan are on the Raritan website at:http://www.raritaneng.com