From my experience, a boat has a much better chance of surviving a hurricane in the water than on the hard. A slip however is not the best place when a storm is approaching, and instead you should either move it to open water or to a wide canal. Open water is preferred as there is less chance of debris and other objects hitting the boat, but you will need several good anchors tied off properly and ensure that they are well set. If that isn't an option, then the next best is a wide canal where you can place the boat directly in the middle of the canal and securely tied to shore on either side with a proper swing line configuration to compensate for the tidal surge. If you have enough advance warning of course, the best thing would be to move the boat to another anchorage that is well out of the way of the storm path.. even just several miles can make a huge difference in winds, waves and tidal surge. If you must keep it in the slip, then try to remove everything on the exterior that you can. Tape down hatches, halyards and anything that might break loose and fly around, and cover any opening that might allow air/water into the boat. Double or triple up on your swing lines if you have enough to do so, and you might want to add a couple extra-long lines just in case the tidal surge snaps your shorter ones.
I grew up in S. Florida, and have been through many, many hurricanes and all of my boats have made it through them except for one.. and that one was on a trailer in my back yard tied to a telephone pole and chain-link fence, staked down, partially filled with water and with deflated tires. Unfortunately, the telephone pole and fence went missing and the boat did a couple of flips across the yard winding up upside down on top of my kids swing set. That was Hurricane Andrew.. and to be fair, my house did not hold up that well either
Edit: I just noticed you have a Mac 22.. then by all means, if you hear of a storm approaching and it looks like it will hit the harbor where you boat is, take the day off and go down and move it to someplace safe. The best chance for a boat to survive a Hurricane is to be no where near it when it hits, and 3 1/2 hours away should be plenty to ensure that! NOAA has
pretty much nailed predicting where these things are going to hit, even several days out to within a pretty narrow area, so you will know if you need to move it or not in advance.
Cheers,
Brad