Come throuh at high slack
water, follow the excellent buoyage and you'll be fine. The dredged channels are deep but shoal out fast at the edges. The prevailing winds are are S to SW, 5-15 kts, less boisterous in the evening. Sayville is worth a visit as is Patchogue. Folks often anchor for the night in the Connetquot River where there are some waterside bar/restaurants you can dock at or dinghy to. You can anchor pretty much anywhere out of the channels and the fish trap areas (of which there are many, check your chart). Marinas are not cheap!