So here's the theory. Most ice boxes drain to the bilge. Dry ice doesn't melt, it sublimes (evaporates) into carbon dioxide gas. This gas will flow out the drain and fill the bilge, displacing oxygen. In time, enough CO2 can accumulate to suffocate you while sleeping, especially in an aft cabin with its berth close to the sole. Could it happen? Seems like it could. Has it happened? Not sure, but I personally don't want to experiment with it to find out. I've considered using it in a cooler in the cockpit, but just don't feel comfortable having it down below.