Difficult to say...
Has anyone calculated the burn rate for a Yanmar 50 on a Hunter410 at about 2000 rpm? I understand that this will vary with conditions, so I am looking at rough figures. I am planning a trip from Victoria, B.C. to San Fran and I attempting to ascertain the amount of diesel I should have as a minimum.
That's an interesting question, and only repeated trips in the same boat could even start to build a set of stats to answer it...

You're not the first mariner to ponder it, either.
I have crewed one trip from Astoria to SF, on a 36 footer. We carried several jerry cans on deck and about 40 gallons in the tank (that's a guess, since it's been a decade). We sailed all but the last 8 hours, closing in on the Golden Gate. No fuel shortage at all!
Prevailing winds are strong to carry you down the coast, and there's almost always a corresponding surface current to assist you.
You can add fuel along the way if needed, of course. It rather depends on how far out you plan to be from the coast. For instance, one good stop with an "easy bar crossing" is @ Newport OR.
Only vital piece of boat equipment, other than the engine to charge batteries, is a really good wind vane. Our Monitor (just one good brand among several choices) worked tirelessly, even through a 36 hour gale while transiting Cape Mendocino.
It's a great trip!