I would go through some prep work first
I would repack the bearings, if they are questionable, i would replace them. I would also invest in an extra hub with studs, bearings (pre-grease them before you leave), castle nut, cotter pin. If you can, get 2. One with out a rotor/drum, whatever you have, and the other with just a hub. A spare tire is a must. 2 is always better than 1. Make sure that the tow rig is tuned up, good tires, brakes, fresh engine and tranny fluid. Other than that, your good to go. FYI I trailered my H22 from Florida to Connecticut and i didn't prep it right, needless to say i had a massive bearing failure in the middle of Orlando. I guess the fun police were on patrol that day. Do yourself a favor and avoid the same misfortune that i had by making sure things are set before you leave, not on the side of an 6 lane highway on a Friday afternoon in the middle of a rather large city.