Shouldn't be a problem
Andy, I understand why people close thru-hulls. I do not think you will loose prime by closing your thru-hull at the dock. Underway can be a different story but much depends on its location to the water line and the location of the pump. I have seen the pick-up high enough on the hull that it can drain when the boat is heeled although that will not be the case with a factory or proper install. Mermaid has a kit available to address loss of prime problems. I don't usually have a prime problem on sailboats unless hauled, then I just unclamp the supply hose at the evap and and take a couple long pulls on the hose. Not as hard as it sounds, most strainers & pumps are located within 3'to 5' of the thru hull and you only have to get the water to the pump not the unit. Just don't board your hot boat and flip the breaker first with other things on your mind like many people do as your unit will fire right up,cool for a few minutes then everything will get real quiet and that will be because your seawater pump ran dry, your compressor head pressure went way up and the high pressure cut-out switch shut everything but the fan down. Easy enough to reset it you know where the manufacturer located the button. They are sometimes buried under the fan or coil out of sight. Hope this helps, just my 2 cents. Have a great day!