I'm pretty sure I could live comfortably (alone) on my Catalina 22, especially if in a marina (hot showers and laundry!), and in a favorable climate. I'd mod the portapotty to an MSD for pump out capability, and rig a nice high boom tent for an outdoor hangout area.
The Admiral and I fully intend to live aboard our Albin Vega 27' for a couple years, beginning in 2020. I honestly think that will be more challenging than living alone on the 22' would be. Relationships ...
EDIT ... I just saw you're 6'3". If there's a problem, that would be it. Then again, I can't stand up straight in the C22 either, unless the hatch is slid forward. Headroom is 5'7, I'm 5'9 and a half or so.